Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | HTR1D | P28221 | 1/20 | 0.30 |
| ▸ | HTR1B | P28222 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5280563 | 0.88 | KMT2A (0.38) | MAPTKDM4EL3MBTL1SMN1; SMN2TSHR | |
| SCHEMBL5288509 | 0.88 | KMT2A (0.36) | MAPTKDM4EHSD17B10TSHRHPGD | |
| SCHEMBL5277972 | 0.81 | MAPT (0.38) | MAPTKDM4EHSD17B10L3MBTL1SMN1; SMN2 | |
| SCHEMBL5279300 | 0.81 | KMT2A (0.40) | MAPTHSD17B10TSHRTDP1 | |
| SCHEMBL6777131 | 0.81 | CYP46A1 (0.39) | MAPTKDM4EHSD17B10HPGDTDP1 | |
| SCHEMBL5281217 | 0.78 | NCEH1 (0.34) | MAPTKDM4EHSD17B10SMN1; SMN2HPGD | |
| SCHEMBL5277022 | 0.76 | THRB (0.36) | MAPTKDM4EHSD17B10TSHRHPGD | |
| SCHEMBL5281418 | 0.76 | KDM4E (0.35) | MAPTKDM4EHSD17B10HPGD | |
| SCHEMBL14342070 | 0.71 | F2 (0.33) | MAPTL3MBTL1SMN1; SMN2 | |
| SCHEMBL6775145 | 0.71 | CYP46A1 (0.41) | MAPTKDM4EHSD17B10TSHRHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1474414-B1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-12-12 | — | — | EP | disclosed |
| EP-1474414-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | Aventis Pharma Deutschland GmbH (DE) | 2004-11-10 | — | — | EP | disclosed |
| WO-2003066620-A1 | DIHYDRO-THIA-PHENANTHRENE-CARBONYL-GUANIDINES, METHOD FOR THE PRODUCTION THEREOF, USE THEREOF AS A MEDICAMENT OR DIAGNOSTIC REAGENT | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2003-08-14 | — | — | WO | disclosed |