Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 4/20 | 0.42 |
| ▸ | TERT | O14746 | 2/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6447306 | 0.82 | PDE5A (0.58) | PDE5A | |
| SCHEMBL6446691 | 0.70 | PDE5A (0.49) | PDE5ATERT | |
| SCHEMBL6447590 | 0.70 | FDPS (0.35) | PDE5ANR3C1 | |
| SCHEMBL6779389 | 0.70 | PDE5A (0.43) | PDE5ATERT | |
| SCHEMBL6778323 | 0.70 | PDE5A (0.40) | PDE5ATERTNR3C1 | |
| SCHEMBL6777164 | 0.69 | PDE5A (0.67) | PDE5A | |
| SCHEMBL6442012 | 0.68 | PDE5A (0.70) | PDE5A | |
| SCHEMBL6782080 | 0.68 | PDE5A (0.48) | PDE5ANR3C1 | |
| SCHEMBL6778371 | 0.67 | TERT (0.41) | PDE5ATERTNR3C1 | |
| SCHEMBL3586129 | 0.67 | PDE5A (0.63) | PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6756373-B1 | SUCH AS 5-(2-BUTOXY-5-IODO-3-PYRIDINYL)-3-ETHYL-2-(2-METHOXY-ETHYL)-2,6-DIHYDRO-7H -PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE; CYCLIC GUANOSINE 3',5'-MONOPHOSPHATE PHOSPHODIESTERASE INHIBITORS; ERECTILE DYSFUNCTION | PFIZER INC. | 2004-06-29 | — | — | US | disclosed |