Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.44 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.44 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.41 |
| ▸ | PDE4A | P27815 | 3/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6771081 | 0.86 | ALDH1A1 (0.58) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL6769419 | 0.86 | SRC (0.47) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL6770366 | 0.85 | SRC (0.56) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL6162867 | 0.85 | ALDH1A1 (0.49) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL6766537 | 0.83 | ALDH1A1 (0.41) | ALDH1A1MAPTLMNAHTTABCG2 | |
| SCHEMBL6770581 | 0.83 | ALDH1A1 (0.62) | ALDH1A1LMNACA1TP53KMT2A | |
| SCHEMBL6778055 | 0.81 | SRC (0.43) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL6766574 | 0.80 | ALDH1A1 (0.39) | ALDH1A1MAPTLMNAHTTDCTPP1 | |
| SCHEMBL6771294 | 0.80 | SRC (0.49) | ALDH1A1MAPTLMNAHTTTSHR | |
| SCHEMBL6772956 | 0.80 | SRC (0.49) | ALDH1A1MAPTLMNAHTTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | disclosed |