Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 8/20 | 0.38 |
| ▸ | ABCG2 | Q9UNQ0 | 7/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6333060 | 1.00 | ABCB1 (0.38) | ABCB1ABCG2HTR2AGRM2KDM4E | |
| SCHEMBL6333056 | 1.00 | ABCB1 (0.38) | ABCB1ABCG2HTR2AGRM2KDM4E | |
| SCHEMBL6338906 | 0.91 | ABCB1 (0.41) | ABCB1ABCG2HTR2AGRM2OPRM1 | |
| SCHEMBL6338894 | 0.91 | ABCB1 (0.41) | ABCB1ABCG2HTR2AGRM2OPRM1 | |
| SCHEMBL6332927 | 0.89 | L3MBTL1 (0.48) | KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL6332932 | 0.89 | L3MBTL1 (0.48) | KDM4EL3MBTL1SMN1; SMN2 | |
| SCHEMBL5787208 | 0.87 | ABCB1 (0.44) | ABCB1ABCG2HTR2AKDM4EL3MBTL1 | |
| SCHEMBL5787213 | 0.87 | ABCB1 (0.44) | ABCB1ABCG2HTR2AKDM4EL3MBTL1 | |
| SCHEMBL6340195 | 0.86 | ACHE (0.42) | ABCB1ABCG2 | |
| SCHEMBL6340187 | 0.86 | ACHE (0.42) | ABCB1ABCG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6794395-B1 | Substituted indolinones, their manufacture and their use as medicaments | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2004-09-21 | — | — | US | disclosed |