Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.31 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.31 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.31 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL1582634 | 0.86 | TDP1 (0.41) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| SCHEMBL301134 | 0.86 | TDP1 (0.45) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| SCHEMBL4326950 | 0.84 | TDP1 (0.43) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| Iodide SCHEMBL1478204 | 0.84 | TDP1 (0.43) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| Bromide SCHEMBL28443974 | 0.84 | TDP1 (0.43) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| Bromide SCHEMBL29193727 | 0.84 | TDP1 (0.43) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| Bromide SCHEMBL1582391 | 0.81 | TDP1 (0.41) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| Ethane SCHEMBL5755629 | 0.81 | CYP3A4 (0.45) | CYP3A4TDP1ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL5764560 | 0.80 | SLC6A2 (0.31) | CYP3A4TDP1SLC6A2TAAR1MAOA | |
| Hydrochloric Acid SCHEMBL7933432 | 0.78 | CYP3A4 (0.35) | CYP3A4TDP1ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 90 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11746091-B2 | Cannabinoid receptor modulators | ARENA PHARMACEUTICALS, INC. (US) | 2023-09-05 | — | — | US | disclosed |
| US-11214548-B2 | Cannabinoid receptor modulators | ARENA PHARMACEUTICALS, INC. (US) | 2022-01-04 | — | — | US | disclosed |
| US-20210188781-A1 | CANNABINOID RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. | 2021-06-24 | — | — | US | disclosed |
| US-20180354907-A1 | CANNABINOID RECEPTOR MODULATORS | ARENA PHARMACEUTICALS, INC. | 2018-12-13 | — | — | US | disclosed |
| EP-3363788-A1 | CANNABINOID RECEPTOR MODULATORS | Arena Pharmaceuticals, Inc. (US) | 2018-08-22 | — | — | EP | disclosed |
| US-9944606-B2 | Cannabinoid receptor modulators | ARENA PHARMACEUTICALS, INC. (US) | 2018-04-17 | — | — | US | disclosed |
| EP-2855455-B1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | HOFFMANN LA ROCHE (CH) | 2017-11-08 | — | — | EP | disclosed |
| US-9394311-B2 | Triazolo compounds as PDE10 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2016-07-19 | — | — | US | disclosed |
| EP-1690847-B1 | pi-conjugated compound having cardo structure, process for the preparation thereof and use thereof | TOSOH CORP (JP) | 2016-06-22 | — | — | EP | disclosed |
| US-20150148332-A1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 2015-05-28 | — | — | US | disclosed |
| US-5164393-A | PYRIMIDINE DERIVATIVES COMPOSITIONS CONTAINING THEM, AND THEIR USE AS FUNGICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-11-17 | — | — | US | disclosed |
| US-5160661-A | DIOXANYLPYRIDINE | HOFFMANN-LA ROCHE INC. (US) | 1992-11-03 | — | — | US | disclosed |
| EP-0500755-A1 | PYRIDINE DERIVATIVES, PROCESS FOR MAKING THEM, AGENTS CONTAINING THEM AND THEIR USE AS FUNGICIDES. | HOECHST AG (DE) | 1992-09-02 | — | — | EP | disclosed |
| EP-0481405-A1 | Pyrimidin derivatives, process for their préparation, agents containing them and their use as fungicides | Hoechst Schering AgrEvo GmbH (DE) | 1992-04-22 | — | — | EP | disclosed |
| US-5104569-A | LIQUID CRYSTALLINE MIXTURES INCLUDING 2-PHENYLPYRIDINE COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1992-04-14 | — | — | US | disclosed |
| US-5059572-A | Diphosphine complex of nickel carboxylate or sulfonate; used in synthesis of bisbenzocyclobutenes | SHELL OIL COMPANY | 1991-10-22 | — | — | US | disclosed |
| EP-0433835-A2 | Dioxanylpyridines | F. HOFFMANN-LA ROCHE AG (CH) | 1991-06-26 | — | — | EP | disclosed |
| WO-1991007399-A1 | PYRIDINE DERIVATIVES, PROCESS FOR MAKING THEM, AGENTS CONTAINING THEM AND THEIR USE AS FUNGICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-30 | — | — | WO | disclosed |
| WO-1991007400-A1 | PYRIMIDINE DERIVATIVES, PROCESS FOR MAKING THEM, AGENTS CONTAINING THEM AND THEIR USE AS FUNGICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-05-30 | — | — | WO | disclosed |
| EP-0391203-A2 | 2-Phenyl pyridins | F. HOFFMANN-LA ROCHE AG (CH) | 1990-10-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180354907-A1 | CANNABINOID RECEPTOR MODULATORS | CNR1, CNR2, TRPV1 | SLC6A2 4164/4885SLC6A3 3967/4885CYP3A4 2898/4885 |
| US-20150148332-A1 | TRIAZOLO COMPOUNDS AS PDE10 INHIBITORS | PDE3A, PDE3B, PDE5A | SLC6A2 1515/4885SLC6A3 637/4885CYP3A4 425/4885 |
| US-11746091-B2 | Cannabinoid receptor modulators | CNR1, CNR2, TRPV1 | SLC6A2 4164/4885SLC6A3 3967/4885CYP3A4 2898/4885 |
| US-11214548-B2 | Cannabinoid receptor modulators | CNR1, CNR2, TRPV1 | SLC6A2 4164/4885SLC6A3 3967/4885CYP3A4 2898/4885 |
| US-20210188781-A1 | CANNABINOID RECEPTOR MODULATORS | CNR1, CNR2, TRPV1 | SLC6A2 4164/4885SLC6A3 3967/4885CYP3A4 2898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.