Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | DPP4 | P27487 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566663 | 0.87 | KMT2A (0.51) | KDM4ETSHRALDH1A1SMN1; SMN2HSP90AA1 | |
| SCHEMBL7507492 | 0.84 | KDM4E (0.44) | KDM4ETSHRALDH1A1SMN1; SMN2HSP90AA1 | |
| SCHEMBL8322260 | 0.84 | DPP4 (0.48) | KDM4ETSHRHSP90AA1DPP4RAB9A | |
| SCHEMBL8324234 | 0.81 | DPP4 (0.51) | KDM4ETSHRSMN1; SMN2HSP90AA1DPP4 | |
| SCHEMBL1905334 | 0.78 | KMT2A (0.49) | KDM4ETSHRALDH1A1SMN1; SMN2HSP90AA1 | |
| SCHEMBL8558823 | 0.77 | PDE4B (0.59) | ALDH1A1SMN1; SMN2NPSR1NPC1TP53 | |
| SCHEMBL11393991 | 0.77 | MAPT (0.48) | KDM4EALDH1A1MAPK1NPSR1TP53 | |
| SCHEMBL2911498 | 0.77 | MEN1 (0.52) | KDM4EALDH1A1SMN1; SMN2DPP4MAPK1 | |
| Hydrochloric Acid SCHEMBL8567867 | 0.77 | PDE4B (0.58) | ALDH1A1SMN1; SMN2NPSR1NPC1TP53 | |
| SCHEMBL19783662 | 0.76 | THRB (0.45) | KDM4EALDH1A1DPP4MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693114-B2 | N-(4-CHLOROBENZYL)-6-(3-HYDROXY-1-PROPYNYL)-1-7-DIMETHYL-4-OXO-1,4 -DIHYDRO(1,8) NAPHTHYRIDINE-3-CARBOXAMIDE FOR EXAMPLE; INHIBITING VIRAL DNA POLYMERASE; TREATING HERPES VIRUS INFECTIONS | PHARMACIA & UPJOHN COMPANY | 2004-02-17 | — | — | US | disclosed |
| EP-1265895-A1 | 4-OXO-1,4-DIHYDRO 1,8]NAPHTHYRIDINE-3-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| EP-1265896-A1 | 4-HYDROXY-1,8-NAPHTHYRIDINE-3-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-12-18 | — | — | EP | disclosed |
| US-20020177604-A1 | 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents | VAILLANCOURT VALERIE A (US) | 2002-11-28 | — | — | US | disclosed |
| US-6451811-B2 | HERPES VIRUS | PHARMACIA & UPJOHN COMPANY | 2002-09-17 | — | — | US | disclosed |
| US-6413958-B2 | FOR TREATMENT/PREVENTION OF INFECTION OF HERPES SIMPLEX VIRUS, VARICELLA ZOSTER VIRUS, HUMAN CYTOMEGALOVIRUS, OR EPSTEIN-BARR VIRUS; ENZYME INHIBITORS | PHARMACIA & UPJOHN COMPANY | 2002-07-02 | — | — | US | disclosed |
| US-20020019413-A1 | 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-02-14 | — | — | US | disclosed |
| US-20020007066-A1 | 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents | PHARMACIA & UPJOHN COMPANY | 2002-01-17 | — | — | US | disclosed |
| WO-2001074816-A1 | 4-OXO-1,4-DIHYDRO[1,8]NAPHTHYRIDINE-3-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-10-11 | — | — | WO | disclosed |
| WO-2001070742-A1 | 4-HYDROXY-1,8-NAPHTHYRIDINE-3-CARBOXAMIDES AS ANTIVIRAL AGENTS | PHARMACIA & UPJOHN COMPANY (US) | 2001-09-27 | — | — | WO | disclosed |
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020019413-A1 | 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents | IRF3, ZC3HAV1, EIF2AK2 | KDM4E 273/4885TSHR 4800/4885ALDH1A1 783/4885 |
| US-20020177604-A1 | 4-oxo-1,4-dihydro[1,8]naphthyridine-3-carboxamides as antiviral agents | IRF3, ZC3HAV1, EIF2AK2 | KDM4E 273/4885TSHR 4800/4885ALDH1A1 783/4885 |
| US-20020007066-A1 | 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents | CNR1, HAVCR2, NR1H4 | KDM4E 1068/4885TSHR 755/4885ALDH1A1 3837/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.