Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324234 | 0.91 | DPP4 (0.51) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL8324245 | 0.88 | TSHR (0.42) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL8327645 | 0.87 | KMT2A (0.51) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL8328855 | 0.87 | DPP4 (0.40) | DPP4TSHR | |
| SCHEMBL8558995 | 0.86 | DPP4 (0.46) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL8562829 | 0.86 | ALDH1A1 (0.38) | DPP4TSHR | |
| SCHEMBL7507492 | 0.84 | KDM4E (0.44) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL6780202 | 0.84 | KDM4E (0.44) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL8560147 | 0.81 | DPP4 (0.42) | DPP4KDM4ENPC1MAPTTSHR | |
| SCHEMBL8560142 | 0.81 | DPP4 (0.42) | DPP4KDM4ENPC1MAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705260-B1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1999-03-03 | — | — | EP | disclosed |
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5780482-A | TREATING RHEUMATIC DISEASES | KNOLL AKTIENGESELLSCHAFT (DE) | 1998-07-14 | — | — | US | disclosed |
| EP-0705260-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AKTIENGESELLSCHAFT (DE) | 1996-04-10 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1995000511-A1 | CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY | KNOLL AG (DE) | 1995-01-05 | — | — | WO | disclosed |
| EP-0618916-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | Knoll AG (DE) | 1994-10-12 | — | — | EP | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |
| EP-0008610-B1 | FURONAPHTHYRIDINE COMPOUNDS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | DAIICHI SEIYAKU CO., LTD. (JP) | 1981-10-14 | — | — | EP | disclosed |
| US-4293695-A | ANTIBACTERIAL AGENTS | DAIICHI SEIYAKU CO., LTD. (JP) | 1981-10-06 | — | — | US | disclosed |
| EP-0008610-A1 | Furonaphthyridine compounds, process for their preparation and pharmaceutical compositions containing them | DAIICHI SEIYAKU CO., LTD. (JP) | 1980-03-19 | — | — | EP | disclosed |