Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 12/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.56 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.56 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782571 | 0.85 | GRIA4 (0.76) | GRIA4GRIA2GRIA1GRIA3ALDH1A1 | |
| SCHEMBL6783524 | 0.84 | GRIA4 (0.55) | GRIA4GRIA2GRIA1GRIA3ALDH1A1 | |
| SCHEMBL6782561 | 0.84 | GRIA4 (0.68) | GRIA4GRIA2GRIA1GRIA3ALDH1A1 | |
| SCHEMBL6784166 | 0.83 | GRIA4 (0.60) | GRIA4GRIA2GRIA1GRIA3TDP1 | |
| SCHEMBL6783556 | 0.81 | GRIA4 (0.60) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6780379 | 0.80 | GRIA4 (0.55) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6782446 | 0.80 | GRIA4 (0.66) | GRIA4GRIA2GRIA1GRIA3ALDH1A1 | |
| SCHEMBL6782230 | 0.79 | GRIA4 (0.55) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6779663 | 0.79 | LMNA (0.58) | GRIA4GRIA2GRIA1GRIA3SMN1; SMN2 | |
| SCHEMBL6779076 | 0.79 | GRIA4 (0.56) | GRIA4GRIA2GRIA1GRIA3RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693137-B1 | GLUTAMATE RECEPTOR POTENTIATION | ELI LILLY AND COMPANY | 2004-02-17 | — | — | US | claimed |
| US-6693137-B1 | GLUTAMATE RECEPTOR POTENTIATION | ELI LILLY AND COMPANY | 2004-02-17 | — | — | US | disclosed |
| EP-0994110-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0994110-A1 | Sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| WO-2000006148-A1 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |