Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 17/20 | 0.60 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782230 | 0.91 | GRIA4 (0.55) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6780379 | 0.88 | GRIA4 (0.55) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6783524 | 0.87 | GRIA4 (0.55) | GRIA4GRIA2GRIA1GRIA3L3MBTL1 | |
| SCHEMBL6782561 | 0.86 | GRIA4 (0.68) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6780319 | 0.83 | GRIA4 (0.56) | GRIA4GRIA2GRIA1GRIA3L3MBTL1 | |
| SCHEMBL6782446 | 0.83 | GRIA4 (0.66) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL5877947 | 0.82 | GRIA4 (0.61) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6779663 | 0.81 | LMNA (0.58) | GRIA4GRIA2GRIA1GRIA3L3MBTL1 | |
| SCHEMBL6782732 | 0.81 | GRIA4 (0.51) | GRIA4GRIA2GRIA1GRIA3 | |
| SCHEMBL6779076 | 0.81 | GRIA4 (0.56) | GRIA4GRIA2GRIA1GRIA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693137-B1 | GLUTAMATE RECEPTOR POTENTIATION | ELI LILLY AND COMPANY | 2004-02-17 | — | — | US | claimed |
| US-6693137-B1 | GLUTAMATE RECEPTOR POTENTIATION | ELI LILLY AND COMPANY | 2004-02-17 | — | — | US | disclosed |
| EP-0994110-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0994110-A1 | Sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| WO-2000006148-A1 | SULPHONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2000-02-10 | — | — | WO | disclosed |