Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | PPARG | P37231 | 11/20 | 0.51 |
| ▸ | F10 | P00742 | 5/20 | 0.49 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.48 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.48 |
| ▸ | CCR2 | P41597 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3578136 | 0.90 | PPARG (0.54) | PPARGF10NOD2NOD1CCR2 | |
| SCHEMBL12930106 | 0.87 | NOD2 (0.58) | PPARGF10NOD2NOD1CCR2 | |
| SCHEMBL6782501 | 0.85 | ABCB11 (0.58) | ABCB11F10NOD2NOD1CCR2 | |
| SCHEMBL1054163 | 0.85 | NOD2 (0.55) | PPARGF10NOD2NOD1CCR2 | |
| SCHEMBL3571653 | 0.85 | NOD2 (0.67) | PPARGF10NOD2NOD1 | |
| SCHEMBL925921 | 0.85 | F10 (0.51) | PPARGF10NOD2NOD1CCR2 | |
| SCHEMBL7087368 | 0.84 | ABCB11 (0.52) | ABCB11F10NOD2NOD1CCR2 | |
| SCHEMBL7083815 | 0.83 | ABCB11 (0.61) | ABCB11F10NOD2NOD1CCR2 | |
| SCHEMBL7084148 | 0.83 | ABCB11 (0.61) | ABCB11F10NOD2NOD1CCR2 | |
| SCHEMBL3979074 | 0.82 | F10 (0.52) | PPARGF10NOD2NOD1CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6737435-B1 | ANTIINFLAMMATORY AGENTS; MONOCYTE CHEMOATTRACTANT PROTEIN-1 (MCP-1) DISEASES | ASTRAZENECA AB (SE) | 2004-05-18 | — | — | US | disclosed |
| EP-1150952-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 RECEPTOR ANTAGONISTS | AstraZeneca AB (SE) | 2001-11-07 | — | — | EP | disclosed |
| WO-2000046196-A1 | INDOLE DERIVATIVES AND THEIR USE AS MCP-1 ANTAGONISTS | ASTRAZENECA AB (SE) | 2000-08-10 | — | — | WO | disclosed |