Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 13/20 | 0.39 |
| ▸ | HTR1D | P28221 | 11/20 | 0.39 |
| ▸ | GHSR | Q92847 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6784076 | 0.84 | DRD3 (0.39) | HTR1BHTR1DGHSRDRD2DRD3 | |
| SCHEMBL6608567 | 0.77 | NOTUM (0.53) | HTR1BHTR1DHTR1AMAPT | |
| SCHEMBL6608569 | 0.77 | NOTUM (0.53) | HTR1BHTR1DHTR1AMAPT | |
| SCHEMBL16301363 | 0.71 | ALDH1A1 (0.46) | DRD2DRD3KDM4E | |
| SCHEMBL6839605 | 0.69 | NOTUM (0.55) | KDM4EGAAMAPTHTTRECQL | |
| SCHEMBL10817749 | 0.69 | DRD1 (0.53) | DRD2DRD3MAPT | |
| SCHEMBL6603840 | 0.69 | GFER (0.39) | GHSRDRD2HTR6TGFBR1ACVR1 | |
| SCHEMBL6603837 | 0.69 | GFER (0.39) | GHSRDRD2HTR6TGFBR1ACVR1 | |
| SCHEMBL21388458 | 0.67 | ADRB1 (0.49) | DRD2DRD3KDM4EGAAMAPT | |
| SCHEMBL10224205 | 0.67 | ALDH1A1 (0.38) | DRD2DRD3KDM4ERECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2020183011-A1 | HTR1D INHIBITORS AND USES THEREOF IN THE TREATMENT OF CANCER | INSTITUT CURIE (FR) | 2020-09-17 | — | — | WO | disclosed |
| US-6747030-B1 | CIS-6-(3,5-DIMETHYLPIPERAZIN-1-YL)-5-METHOXY-1-(2'-METHYL-4'-( 5-METHYL-1,2,4-OXADIAZOL-3-YL)BIPHENYL-4-CARBONYL)INDOLINE, ITS HYDROCHLORIDE SALT, OR ANOTHER PHARMACEUTICALLY ACCEPTABLE SALT THEREOF; ANTIDEPRESSANTS | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-06-08 | — | — | US | disclosed |