Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.43 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14923513 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL67814 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL30664358 | 0.88 | ATM (0.42) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL20757361 | 0.88 | ATM (0.42) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL19300690 | 0.88 | ATM (0.42) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL20974198 | 0.87 | AKT1 (0.43) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL22559290 | 0.87 | AKT1 (0.43) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL5551909 | 0.87 | CA1 (0.50) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL5551910 | 0.87 | CA1 (0.50) | ALDH1A1MALT1MMP1MMP2MMP3 | |
| SCHEMBL5551903 | 0.87 | CA1 (0.50) | ALDH1A1MALT1MMP1MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160024114-A1 | MACROCYCLIC RIP2 KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2016-01-28 | — | — | US | disclosed |
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| WO-2014140299-A1 | MACROCYCLIC RIP2 KINASE INHIBITORS | ONCODESIGN S.A (FR) | 2014-09-18 | — | — | WO | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-20130096149-A1 | HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-04-18 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | ALDH1A1 3257/4885MALT1 1770/4885MMP1 4784/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | ALDH1A1 2358/4885MALT1 1001/4885MMP1 4766/4885 |
| US-20160024114-A1 | MACROCYCLIC RIP2 KINASE INHIBITORS | RIPK2, RIPK1, RIPK3 | ALDH1A1 4857/4885MALT1 2099/4885MMP1 4371/4885 |
| US-20130096149-A1 | HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS | BRAF, RAF1, ARAF | ALDH1A1 3123/4885MALT1 1008/4885MMP1 4648/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.