Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 11/20 | 0.49 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6716680 | 0.92 | EDNRA (0.52) | EDNRA | |
| SCHEMBL6720416 | 0.89 | EDNRA (0.53) | EDNRAHSPA5SYK | |
| SCHEMBL6715006 | 0.85 | EDNRA (0.52) | EDNRA | |
| SCHEMBL6720603 | 0.84 | EDNRA (0.59) | EDNRAHSPA5SYK | |
| SCHEMBL6716553 | 0.83 | LMNA (0.53) | — | |
| SCHEMBL6720455 | 0.83 | MAPK10 (0.46) | EDNRASYK | |
| SCHEMBL7210296 | 0.82 | PFKFB3 (0.56) | — | |
| SCHEMBL6724931 | 0.81 | EDNRA (0.62) | EDNRA | |
| SCHEMBL6718224 | 0.81 | EDNRA (0.49) | EDNRASYK | |
| SCHEMBL6716520 | 0.79 | EDNRA (0.56) | EDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6818651-B2 | ANTIINFLAMMATORY, ANTIASTHMATIC, SKIN, AND AUTOIMMUNE DISORDERS; CROHN*S DISEASE, ULCERATIVE COLITIS, CONJUCTIVITIS, MULTIPLE SCLEROSIS, AND RHEUMATOID ARTHRITIS; CHRONIC OBSTRUCTIVE PULMONARY DISEASE | ALTANA PHARMA AG (DE) | 2004-11-16 | — | — | US | disclosed |
| EP-1337515-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | Byk Gulden Lomberg Chemische Fabrik GmbH (DE) | 2003-08-27 | — | — | EP | disclosed |
| WO-2002040450-A1 | (DIHYDRO)ISOQUINOLINE DERIVATIVES AS PHOSPHODIESTERASE INHIBITORS | ALTANA PHARMA AG (DE) | 2002-05-23 | — | — | WO | disclosed |