SCHEMBL6782178

SCHEMBL6782178

COc1ccc(/C=C/C=C/C(=O)O)c(OC)c1

nearest known ligand 0.69

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.69
ALDH1A1 P00352 3/20 0.69
MEN1 O00255 2/20 0.69
KMT2A Q03164 2/20 0.69
CYP1A1 P04798 7/20 0.64
CYP1A2 P05177 7/20 0.64
CYP1B1 Q16678 7/20 0.64
NPC1 O15118 2/20 0.63
RAB9A P51151 2/20 0.63
SMN1; SMN2 Q16637 1/20 0.63
TNFRSF1A P19438 1/20 0.62
LY96 Q9Y6Y9 1/20 0.59
MAPK1 P28482 1/20 0.58
NFE2L2 Q16236 2/20 0.57
LMNA P02545 1/20 0.57
HPGD P15428 1/20 0.57
CHRNA7 P36544 1/20 0.56
BACE1 P56817 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10661702 1.00 MAPT (0.69) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL29449851 0.90 MAPT (0.79) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL79457 0.90 MAPT (0.79) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL79456 0.90 MAPT (0.79) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL27892982 0.90 MAPT (0.79) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL15163802 0.89 JUN (0.68) MAPTALDH1A1MEN1KMT2ACYP1A1
Hydrochloric Acid SCHEMBL15299858 0.89 MAPT (0.77) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL27858760 0.89 MAPT (0.77) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL15428890 0.88 JUN (0.66) MAPTALDH1A1MEN1KMT2ACYP1A1
SCHEMBL2032355 0.88 MAPT (0.69) MAPTALDH1A1MEN1KMT2ACYP1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6828316-B2 Antiallergens KOWA CO., LTD. (JP) 2004-12-07 US disclosed
US-20020042414-A1 Diamide compound and medicine containing the same KOWA CO., LTD. (JP) 2002-04-11 US disclosed
US-6340682-B1 FOR THERAPY OF ALLERGIC IMMUNOLOGICAL DISEASE IS SELECTED FROM ASTHMA, ALLERGIC RHINITIS, INFLAMMATORY LARGE BOWEL DISEASE OR CONTACT DERMATITIS KOWA CO., LTD. (JP) 2002-01-22 US disclosed
EP-0926138-A1 DIAMIDE COMPOUNDS AND DRUGS CONTAINING THE SAME KOWA CO. LTD. (JP) 1999-06-30 EP disclosed
US-4792553-A TREATMENT OF CARDIOVASCULAR AND CEREBROVASCULAR DISORDERS TERUMO KABUSHIKI KAISHA (JP) 1988-12-20 US disclosed
EP-0232205-A2 Diene derivatives and vasodilators containing the same TERUMO KABUSHIKI KAISHA trading as TERUMO CORPORATION (JP) 1987-08-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020042414-A1 Diamide compound and medicine containing the same HRH4, HRH2, HRH1 MAPT 3453/4885ALDH1A1 836/4885MEN1 3292/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.