Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 7/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 5/20 | 0.53 |
| ▸ | PARP1 | P09874 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.46 |
| ▸ | STK3 | Q13188 | 2/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.46 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.46 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | ROS1 | P08922 | 1/20 | 0.46 |
| ▸ | PHKG2 | P15735 | 1/20 | 0.46 |
| ▸ | PRKACA | P17612 | 1/20 | 0.46 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6788485 | 0.99 | ROCK1 (0.52) | ROCK1ROCK2PARP1PKMMAP4K4 | |
| SCHEMBL6793264 | 0.88 | ROCK1 (0.58) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| SCHEMBL6787159 | 0.87 | ROCK1 (0.59) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| SCHEMBL6785862 | 0.85 | ROCK1 (0.55) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| SCHEMBL6788685 | 0.84 | ROCK1 (0.54) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| SCHEMBL6785736 | 0.83 | HPGD (0.51) | ROCK1ROCK2PARP1ALDH1A1POLB | |
| SCHEMBL6782540 | 0.83 | ROCK1 (0.53) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| SCHEMBL6786459 | 0.83 | ROCK2 (0.53) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| SCHEMBL6785747 | 0.83 | ROCK1 (0.53) | ROCK1ROCK2PARP1MAP4K4PIM1 | |
| Hydrochloric Acid SCHEMBL6782837 | 0.83 | HPGD (0.51) | ROCK1ROCK2PARP1ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677333-B1 | ANTIISCHEMIC AGENTS; BRAIN, CARDIOVASCULAR, MUSCULAR, AND GASTROINTESTINAL DISORDERS; ANALGESICS, ANTIDIABETIC AGENTS; RETROVIRUS SENSITIZERS; ALZHEIMER*S DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| EP-1148053-A1 | 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | claimed |