SCHEMBL6783258

SCHEMBL6783258

Cc1cc(C)nc(SCC(CS(=O)(=O)c2ccc(-c3ccc(Cl)cc3)cc2)C(=O)O)n1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HPGD P15428 3/20 0.44
ALDH1A1 P00352 4/20 0.43
CA12 O43570 1/20 0.41
CA1 P00915 1/20 0.41
CA2 P00918 1/20 0.41
CA6 P23280 1/20 0.41
CA7 P43166 1/20 0.41
CA13 Q8N1Q1 1/20 0.41
MMP2 P08253 7/20 0.40
MMP9 P14780 5/20 0.40
MMP3 P08254 4/20 0.40
MMP13 P45452 3/20 0.40
MMP1 P03956 2/20 0.40
MMP8 P22894 1/20 0.40
LMNA P02545 2/20 0.39
L3MBTL1 Q9Y468 2/20 0.39
MAPT P10636 1/20 0.39
PKM P14618 1/20 0.39
HSD17B10 Q99714 1/20 0.38
HSP90AA1 P07900 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7447846 1.00 HPGD (0.44) HPGDALDH1A1CA12CA1CA2
SCHEMBL6788329 0.94 HPGD (0.39) HPGDALDH1A1CA12CA1CA2
SCHEMBL6784835 0.88 MMP2 (0.41) HPGDALDH1A1MMP2MMP9MMP3
SCHEMBL6789943 0.86 ALDH1A1 (0.43) HPGDALDH1A1MMP2MMP9MMP3
SCHEMBL6788702 0.83 MMP2 (0.45) CA12CA1CA2CA6CA7
SCHEMBL6794032 0.83 MMP2 (0.39) HPGDALDH1A1MMP2MMP9MMP3
SCHEMBL6789717 0.80 MMP2 (0.51) ALDH1A1MMP2MMP9MMP3MMP13
SCHEMBL6796186 0.79 MMP2 (0.62) MMP2MMP9MMP3MMP13MMP1
SCHEMBL6783118 0.79 MMP2 (0.62) MMP2MMP9MMP3MMP13MMP1
SCHEMBL6783185 0.79 MMP2 (0.62) MMP2MMP9MMP3MMP13MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6765003-B1 ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, PHARMACIA ITALIA, SPA (IT) 2004-07-20 US disclosed
EP-1200398-A1 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2002-05-02 EP disclosed
WO-2001005756-A1 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN SPA (IT) 2001-01-25 WO disclosed