Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 4/20 | 1.00 |
| ▸ | CES2 | O00748 | 2/20 | 0.61 |
| ▸ | CES1 | P23141 | 2/20 | 0.61 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.55 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.52 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.46 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.46 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | MMP1 | P03956 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL786834 | 0.84 | GSK3B (0.72) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL9644843 | 0.82 | GSK3B (0.76) | GSK3BCES2CES1SRD5A2PDPK1 | |
| SCHEMBL10847368 | 0.81 | CES2 (0.69) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL3366395 | 0.79 | GSK3B (0.66) | GSK3BSRD5A2MEN1TSHRKMT2A | |
| SCHEMBL8534398 | 0.79 | GSK3B (0.66) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL9022367 | 0.78 | GSK3B (0.64) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL3107743 | 0.78 | GSK3B (0.64) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL5052384 | 0.78 | GSK3B (0.64) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL2181232 | 0.78 | CES2 (0.70) | GSK3BCES2CES1PTPN1SRD5A2 | |
| SCHEMBL8553654 | 0.78 | CES2 (0.65) | GSK3BCES2CES1PTPN1SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546126-B1 | PROCESS FOR PRODUCING TRIFLUOROMETHYL-SUBSTITUTED 2-ALKOXYACETOPHENONE DERIVATIVES | CENTRAL GLASS CO LTD (JP) | 2007-11-21 | — | — | EP | disclosed |
| US-7189863-B2 | Process for producing trifluoromethyl-substituted 2-alkoxyacetophenone derivatives | CENTRAL GLASS COMPANY, LIMITED (JP) | 2007-03-13 | — | — | US | disclosed |
| US-6747057-B2 | SUCH 1-(2-BROMO-4,5-DICHLORO-THIOPHEN-3-YL)-2-CHLORO-ETHANONE FOR TREATMENT OF ALZHEIMER'S DISEASE OR DIABETES | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2004-06-08 | — | — | US | disclosed |
| US-20030199508-A1 | Compounds and their therapeutic use | UNIVERSIDAD AUTONOMA DE MADRID (UAM) (ES) | 2003-10-23 | — | — | US | disclosed |
| WO-2003055479-A1 | COMPOUNDS AND THEIR THERAPEUTIC USE RELATED TO THE PHOSPHORYLATING ACTIVITY OF THE ENZYME GSK-3 | CONSEJO SUPERIOR DE INVESTIGACIONES CIENTIFICAS (ES) | 2003-07-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199508-A1 | Compounds and their therapeutic use | CNKSR1, CBR1, CBR3 | GSK3B 4/4885CES2 215/4885CES1 210/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.