Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.49 |
| ▸ | TLR7 | Q9NYK1 | 8/20 | 0.49 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | CASP6 | P55212 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
| ▸ | CCR1 | P32246 | 1/20 | 0.33 |
| ▸ | CCR8 | P51685 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1528010 | 0.80 | TLR8 (0.69) | TLR8TLR7 | |
| SCHEMBL1527960 | 0.71 | TLR8 (0.67) | TLR8TLR7 | |
| SCHEMBL5765345 | 0.71 | TLR8 (0.48) | TLR8TLR7 | |
| SCHEMBL3797110 | 0.67 | CASP6 (0.44) | IDO1CASP6LMNAHSP90AA1HSP90AB1 | |
| SCHEMBL5790821 | 0.66 | TLR8 (0.50) | TLR8TLR7 | |
| SCHEMBL1528149 | 0.66 | TLR8 (1.00) | TLR8TLR7 | |
| SCHEMBL21849073 | 0.65 | LMNA (0.43) | CASP6LMNAHSP90AA1HSP90AB1CCR1 | |
| SCHEMBL31026572 | 0.65 | CCR1 (0.54) | TLR8IDO1PDPK1LMNAHSP90AA1 | |
| SCHEMBL10688894 | 0.65 | SMN1; SMN2 (0.37) | TLR8TLR7LMNACCR1CCR8 | |
| SCHEMBL1148845 | 0.64 | HRH1 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6703402-B2 | IMMUNOMODULATORS; INDUCERS OF CYTOKINE BIOSYNTHESIS INCLUDING INTERFERON AND/OR TUMOR NECROSIS FACTOR; ANTITUMOR AGENTS, VIRICIDES | 3M INNOVATIVE PROPERTIES COMPANY | 2004-03-09 | — | — | US | disclosed |