Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | PLK1 | P53350 | 1/20 | 0.53 |
| ▸ | DRD4 | P21917 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.51 |
| ▸ | DRD3 | P35462 | 1/20 | 0.51 |
| ▸ | LTA4H | P09960 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14134296 | 0.94 | MAPT (0.60) | MAPTKDM4EALDH1A1PLK1DRD4 | |
| SCHEMBL681577 | 0.94 | MAPT (0.60) | MAPTKDM4EALDH1A1PLK1DRD4 | |
| SCHEMBL31000390 | 0.91 | MAPT (0.58) | MAPTKDM4EALDH1A1PLK1DRD4 | |
| N-Propyl Bromide SCHEMBL9703833 | 0.88 | MAPT (0.55) | MAPTKDM4EALDH1A1PLK1DRD4 | |
| SCHEMBL9155411 | 0.88 | MAPT (0.55) | MAPTKDM4EALDH1A1DRD4DRD2 | |
| SCHEMBL29151586 | 0.85 | MAPT (0.61) | MAPTKDM4EALDH1A1PLK1DRD4 | |
| SCHEMBL916469 | 0.85 | LTA4H (0.57) | MAPTKDM4EALDH1A1DRD4DRD2 | |
| SCHEMBL7254241 | 0.83 | MAPT (0.51) | MAPTKDM4EALDH1A1DRD4DRD2 | |
| Dimethylamine SCHEMBL6788804 | 0.83 | NQO1 (0.64) | MAPTKDM4EALDH1A1PLK1DRD4 | |
| SCHEMBL31000372 | 0.83 | LTA4H (0.55) | MAPTKDM4EALDH1A1DRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693137-B1 | GLUTAMATE RECEPTOR POTENTIATION | ELI LILLY AND COMPANY | 2004-02-17 | — | — | US | disclosed |
| EP-0994110-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0994110-A1 | Sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |