Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NQO1 | P15559 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | PLK1 | P53350 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.47 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9773252 | 0.98 | NQO1 (0.61) | NQO1TDP1TSHRPLK1MAOB | |
| SCHEMBL18358 | 0.93 | NQO1 (0.74) | NQO1TDP1TSHRMAOBLTA4H | |
| SCHEMBL9804312 | 0.91 | NQO1 (0.70) | NQO1TDP1TSHRMAOBLTA4H | |
| Bromoethane SCHEMBL9702775 | 0.88 | NQO1 (0.67) | NQO1TDP1TSHRMAOBLTA4H | |
| Methyl Alcohol SCHEMBL27383198 | 0.88 | NQO1 (0.67) | NQO1TDP1TSHRPLK1MAOB | |
| SCHEMBL6610130 | 0.86 | NQO1 (0.64) | NQO1TDP1TSHRMAOBLTA4H | |
| Dimethylamine SCHEMBL6784757 | 0.83 | MAPT (0.59) | PLK1LTA4HMAPTKDM4EALDH1A1 | |
| SCHEMBL457693 | 0.83 | NQO1 (0.58) | NQO1TDP1TSHRMAOBLTA4H | |
| SCHEMBL8085396 | 0.83 | NQO1 (0.58) | NQO1TDP1TSHRMAOBLTA4H | |
| SCHEMBL9789496 | 0.81 | RELA (0.69) | NQO1MAOBMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6693137-B1 | GLUTAMATE RECEPTOR POTENTIATION | ELI LILLY AND COMPANY | 2004-02-17 | — | — | US | disclosed |
| EP-0994110-B1 | Sulphonamide derivatives | LILLY CO ELI (US) | 2003-05-14 | — | — | EP | disclosed |
| EP-0994110-A1 | Sulphonamide derivatives | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| US-5043332-A | Novel 11β-substituted -19-nor-steriods | ROUSSEL UCLAF (FR) | 1991-08-27 | — | — | US | disclosed |
| US-4978657-A | Antiprogesterones, antiglucocorticoids | ROUSSEL UCLAF (FR) | 1990-12-18 | — | — | US | disclosed |
| US-4900725-A | CONTRACEPTIVES | ROUSSEL UCLAF (FR) | 1990-02-13 | — | — | US | disclosed |
| US-4634695-A | GLUCOCORTICOID INHIBITORS | ROUSSEL UCLAF (FR) | 1987-01-06 | — | — | US | disclosed |
| US-4519946-A | ANTIARTHRITIC, ANTIDIABETIC, ANTISECRETORY, AND HYPOTENSIVE AGENTS | ROUSSEL UCLAF (FR) | 1985-05-28 | — | — | US | disclosed |
| US-4447424-A | ANTIFERTILITY, ANTIINFLAMMATORY AGENT, HORMONE INHIBITOR | ROUSSEL UCLAF (FR) | 1984-05-08 | — | — | US | disclosed |
| US-4386085-A | ANTIGLUCOCORTICOIDS | ROUSSELL UCLAF (FR) | 1983-05-31 | — | — | US | disclosed |