Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 19/20 | 0.45 |
| ▸ | MMP9 | P14780 | 11/20 | 0.40 |
| ▸ | MMP13 | P45452 | 11/20 | 0.40 |
| ▸ | MMP1 | P03956 | 9/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP14 | P50281 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6786265 | 0.85 | ADAM17 (0.44) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6788057 | 0.81 | ADAM17 (0.44) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6788454 | 0.78 | MEN1 (0.39) | CYP3A4 | |
| SCHEMBL6785653 | 0.74 | ADAM17 (0.49) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6782404 | 0.74 | ADAM17 (0.44) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6654467 | 0.73 | ADAM17 (0.65) | ADAM17MMP9MMP13MMP1 | |
| SCHEMBL6788196 | 0.73 | ADAM17 (0.41) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6662235 | 0.72 | ADAM17 (0.48) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6654871 | 0.71 | ADAM17 (0.43) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6656467 | 0.69 | ADAM17 (0.48) | ADAM17MMP9MMP13MMP1MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |