Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 11/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 6/20 | 0.38 |
| ▸ | MMP13 | P45452 | 6/20 | 0.38 |
| ▸ | MMP1 | P03956 | 4/20 | 0.36 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.34 |
| ▸ | RXRB | P28702 | 1/20 | 0.34 |
| ▸ | RXRG | P48443 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | MMP14 | P50281 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785653 | 0.88 | ADAM17 (0.49) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6786265 | 0.88 | ADAM17 (0.44) | ADAM17MMP9MMP13MMP1CYP19A1 | |
| SCHEMBL6787530 | 0.87 | ALDH1A1 (0.44) | ADAM17MMP9MMP13MMP1MEN1 | |
| SCHEMBL6785229 | 0.84 | ADAM17 (0.44) | ADAM17MMP9MMP13MMP1CYP19A1 | |
| SCHEMBL6786027 | 0.83 | ADAM17 (0.43) | ADAM17MMP9MMP13MMP1MMP2 | |
| SCHEMBL6782624 | 0.82 | ADAM17 (0.49) | ADAM17PKMMMP9MMP13MMP1 | |
| SCHEMBL6782404 | 0.81 | ADAM17 (0.44) | ADAM17MMP9MMP13MMP1CYP19A1 | |
| SCHEMBL6655628 | 0.81 | ADAM17 (0.42) | ADAM17MMP9MMP13MMP1CYP19A1 | |
| SCHEMBL6785959 | 0.80 | KIF11 (0.39) | PKMKIF11 | |
| SCHEMBL6787397 | 0.79 | ADAM17 (0.39) | ADAM17MMP9MMP13MMP1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825354-B2 | OSTEOPOROSIS; RHEUMATIC DISEASES | WYETH HOLDINGS CORPORATION | 2004-11-30 | — | — | US | disclosed |
| US-6340691-B1 | TREATMENT OF ARTHRITIS, TUMOR METASTASIS, TISSUE ULCERATION, ABNORMAL WOUND HEALING, PERIODONTAL DISEASE, BONE DISEASE, DIABETES (INSULIN RESISTANCE) AND HIV INFECTION | AMERICAN CYANAMID COMPANY | 2002-01-22 | — | — | US | disclosed |