Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | XDH | P47989 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6785176 | 0.89 | ALDH1A1 (0.46) | ALDH1A1CYP4A11CYP4F2POLBCA12 | |
| SCHEMBL25289661 | 0.85 | HDAC11 (0.49) | ALDH1A1CYP4A11CYP4F2POLBCA12 | |
| SCHEMBL30506566 | 0.85 | HDAC11 (0.49) | ALDH1A1CYP4A11CYP4F2POLBCA12 | |
| SCHEMBL7204369 | 0.85 | TSHR (0.39) | ALDH1A1MAPTGAATDP1CYP2C9 | |
| SCHEMBL1314552 | 0.79 | CYP4A11 (0.55) | CYP4A11CYP4F2POLBCA12CA1 | |
| SCHEMBL31515286 | 0.77 | ALDH1A1 (0.48) | ALDH1A1CYP4A11CYP4F2CA12CA1 | |
| SCHEMBL16799629 | 0.77 | CYP4A11 (0.55) | ALDH1A1CYP4A11CYP4F2POLBCYP2C9 | |
| SCHEMBL31753430 | 0.77 | CYP4A11 (0.55) | ALDH1A1CYP4A11CYP4F2POLBCYP2C9 | |
| SCHEMBL6297936 | 0.76 | ALDH1A1 (0.42) | ALDH1A1MAPTTDP1CYP2C9KDM4E | |
| SCHEMBL6705713 | 0.75 | MGLL (0.44) | ALDH1A1CA12CA1CA2CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784184-B2 | FOR THERAPY OF RAS- ONCOGENE-DEPENDENT TUMORS, SUCH AS CANCERS OF PANCREAS, COLON, BLADDER, AND THYROID; USEFUL FOR CONTROLLING METASTASIS, SUPPRESSING ANGIOGENESIS, INDUCING APOPTOSIS, AND RAS-ASSOCIATED PROLIFERATIVE DISEASES | WYETH HOLDINGS CORPORATION | 2004-08-31 | — | — | US | disclosed |