Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 20/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 16/20 | 0.54 |
| ▸ | ADRA1B | P35368 | 15/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.47 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782749 | 0.81 | ADRA1A (0.48) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6787908 | 0.77 | ADRA1A (0.57) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7237695 | 0.75 | ADRA1A (0.64) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6787008 | 0.74 | ADRA1A (0.52) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7236378 | 0.74 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7954093 | 0.73 | ADRA1A (0.73) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7242493 | 0.73 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6200444 | 0.73 | ADRA1A (0.60) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7245402 | 0.73 | ADRA1A (0.63) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL7251173 | 0.73 | ADRA1A (0.61) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727257-B1 | HYPOTENSIVE AGENTS FOR INTRAOCULAR PRESSURE; ANTICHOLESTEROL AGENTS; RELAXING URINARY TRACT TISSUE; BENIGN PROSTATIC HYPERPLASIA, IMPOTENCY, AND CARDIOVASCULAR DISORDERS; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |
| US-6248747-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA WITH ANTAGONISTS SELECTIVE FOR CLONED HUMAN ALPHA-1C RECEPTORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-06-19 | — | — | US | disclosed |
| US-5942517-A | ANTAGONIST OF ALPHA(1C) RECEPTORS; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |