Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC4 | P56524 | 3/20 | 0.62 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.62 |
| ▸ | SMYD3 | Q9H7B4 | 3/20 | 0.51 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.51 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.51 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.50 |
| ▸ | SLC6A5 | Q9Y345 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.49 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7647671 | 0.89 | RAB9A (0.59) | HDAC4SLC6A5NPC1RAB9ADRD4 | |
| SCHEMBL7652620 | 0.85 | NPC1 (0.68) | HDAC4HDAC6NPC1RAB9ATRPV1 | |
| SCHEMBL7647577 | 0.85 | NPC1 (0.63) | HDAC4HDAC6SLC6A5NPC1RAB9A | |
| SCHEMBL12061861 | 0.84 | MEN1 (0.58) | HDAC4HDAC6SMYD3HDAC3HDAC1 | |
| SCHEMBL1424863 | 0.84 | NPC1 (0.71) | HDAC4HDAC6SMYD3HDAC3HDAC1 | |
| Hydrochloric Acid SCHEMBL4602954 | 0.83 | NPC1 (0.69) | HDAC4HDAC6SMYD3HDAC3HDAC1 | |
| SCHEMBL17927246 | 0.82 | HDAC4 (0.65) | HDAC4NPC1RAB9A | |
| SCHEMBL13575468 | 0.81 | KHK (0.54) | HDAC4HDAC6SMYD3HDAC3HDAC1 | |
| SCHEMBL3036579 | 0.81 | HDAC4 (0.56) | HDAC4HDAC6SMYD3HDAC3HDAC1 | |
| SCHEMBL279571 | 0.81 | RAB9A (0.71) | HDAC4HDAC6SMYD3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | MERCK PATENT GMBH (DE) | 2004-02-19 | — | — | US | disclosed |
| CN-1132828-C | O-substd. hydroxy coumaranone derivs as antineoplastic and antitransfer agent | ROCH DIAGNOSIS EQUIPMENT AG (DE) | 2003-12-31 | — | — | CN | disclosed |
| US-6307051-B1 | UROKINASE-TYPE PLASMINOGEN ACTIVATOR ANTAGONISTS AND HAVE ANTITUMOR AND ANTIMETASTATIC ACTIVITY. | ROCHE DIAGNOSTICS GMBH (DE) | 2001-10-23 | — | — | US | disclosed |
| CN-1266850-A | O-substd. hydroxy coumaranone derivs as antineoplastic and antitransfer agent | ROCH DIAGNOSIS EQUIPMENT AG (DE) | 2000-09-20 | — | — | CN | disclosed |
| EP-1026165-A1 | O-substituted Hydroxycoumaranone derivatives as antitumor and antimetastatic agents | Roche Diagnostics GmbH (DE) | 2000-08-09 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034028-A1 | 4-(biphenylcarbonylamino)piperidine derivatives as mtp inhibitors | LIPC, CETP, MTTP | HDAC4 3777/4885HDAC6 3836/4885SMYD3 3752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.