Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.40 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.39 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.39 |
| ▸ | TOP2A | P11388 | 1/20 | 0.38 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.38 |
| ▸ | FOXO1 | Q12778 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8943879 | 0.78 | TOP2A (0.38) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL8741056 | 0.75 | TOP2A (0.40) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL1344302 | 0.74 | GSK3B (0.40) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL27520234 | 0.74 | NOTUM (0.37) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL8120234 | 0.72 | MEN1 (0.36) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL1345769 | 0.72 | GSK3B (0.70) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL9689537 | 0.70 | GSK3B (0.68) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL1342252 | 0.70 | GSK3B (0.44) | GSK3BCACNA1FPOLBMAPK1CACNA1D | |
| SCHEMBL8129189 | 0.69 | STAT3 (0.31) | — | |
| SCHEMBL27610949 | 0.69 | STAT3 (0.36) | CACNA1FPOLBMAPK1CACNA1DKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6762181-B1 | BROAD ANTIBACTERIAL ACTIVITY INCLUDING DRUG RESISTANT STAPHYLOCOCCUS AUREUS (MRSA), PNEUMOCOCCUS (PRSP) AND ENTEROCOCCUS (VRE); SAFELY USED IN CONJUCTION WITH NONSTEROIDAL ANTIINFLAMMATORY DRUGS | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 2004-07-13 | — | — | US | disclosed |