Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 5/20 | 0.53 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.40 |
| ▸ | ATM | Q13315 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6782071 | 0.89 | TERT (0.64) | TERTLTB4RALDH1A1KDM4EMEN1 | |
| SCHEMBL6784696 | 0.89 | TERT (0.67) | TERTLTB4RALDH1A1KDM4EATM | |
| SCHEMBL6784249 | 0.87 | TERT (0.56) | TERTLTB4RALDH1A1KDM4EMEN1 | |
| SCHEMBL6787614 | 0.85 | KDM4E (0.53) | LTB4RALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6784075 | 0.84 | ALDH1A1 (0.51) | TERTALDH1A1KDM4EATMMEN1 | |
| SCHEMBL6785976 | 0.84 | TERT (0.44) | TERTLTB4RALDH1A1KDM4EATM | |
| SCHEMBL6791903 | 0.83 | TERT (0.43) | TERTLTB4RALDH1A1KDM4EATM | |
| SCHEMBL6785982 | 0.83 | ALDH1A1 (0.46) | LTB4RALDH1A1KDM4EMEN1KMT2A | |
| SCHEMBL6787326 | 0.82 | TERT (0.42) | TERTLTB4RALDH1A1KDM4EATM | |
| SCHEMBL6787843 | 0.81 | TERT (0.61) | TERTLTB4RALDH1A1KDM4EATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727250-B2 | ADMINISTERING COMPOUNDS SUCH AS TRANS-3-(NAPHTH-2-YL)-BUT-2-ENOIC ACID-N-(2-CARBOXY-PHENYL)-AMIDE OR LIKE FOR THERAPY OF CONDITIONS ASSOCIATED WITH INCREASED TELOMERASE ACTIVITY, E.G. TUMOUR DISEASES | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2004-04-27 | — | — | US | disclosed |
| US-6362210-B1 | ANTITUMOR, ANTICANCER AGENT | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2002-03-26 | — | — | US | disclosed |