Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.40 |
| ▸ | MTOR | P42345 | 2/20 | 0.40 |
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | ATR | Q13535 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.38 |
| ▸ | PDE5A | O76074 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 2/20 | 0.36 |
| ▸ | CDK8 | P49336 | 2/20 | 0.36 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.36 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | GAK | O14976 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6783192 | 0.83 | PDE5A (0.41) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL14218822 | 0.81 | PIK3CA (0.42) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL24027143 | 0.81 | PIK3CA (0.42) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL25668139 | 0.78 | NR4A2 (0.46) | HTT | |
| SCHEMBL29940962 | 0.78 | NR4A2 (0.46) | HTT | |
| SCHEMBL27787889 | 0.76 | PIK3CA (0.49) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL18606351 | 0.75 | VCAM1 (0.54) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL30638187 | 0.75 | VCAM1 (0.54) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL25498102 | 0.75 | PDE5A (0.43) | PIK3CAPIK3CBMTORPRKDCATM | |
| SCHEMBL633785 | 0.75 | CDK8 (0.48) | IRAK4PDE5AHTTMAP4K4GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6809106-B1 | ANTIPROLIFERATION AGENTS; SUCH AS 4-(2-METHOXYPHENOXY)-ANILINO-3-CHLORO-6,7-DIMETHOXYQUINOLINE | ASTRAZENECA AB (SE) | 2004-10-26 | — | — | US | disclosed |
| EP-1178966-B1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2003-10-22 | — | — | EP | disclosed |
| CN-1352635-A | Quinoline derivatives as MEK enzyme inhibitors | ASTRAZENECA AB (SE) | 2002-06-05 | — | — | CN | disclosed |
| EP-1178966-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | AstraZeneca AB (SE) | 2002-02-13 | — | — | EP | disclosed |
| WO-2000068200-A1 | QUINOLINE DERIVATIVES AS INHIBITORS OF MEK ENZYMES | ASTRAZENECA AB (SE) | 2000-11-16 | — | — | WO | disclosed |