Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.51 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.51 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | PARP1 | P09874 | 4/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.50 |
| ▸ | FLT1 | P17948 | 2/20 | 0.50 |
| ▸ | KDR | P35968 | 2/20 | 0.50 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | TACR2 | P21452 | 2/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6786529 | 0.99 | HPGD (0.51) | HPGDSMN1; SMN2MAPTMAPK8MAPK10 | |
| SCHEMBL6786857 | 0.90 | CYP3A4 (0.59) | HPGDMAPTMAPK8MAPK10MAPK14 | |
| Hydrochloric Acid SCHEMBL6793755 | 0.90 | CYP3A4 (0.58) | HPGDMAPTMAPK8MAPK10MAPK14 | |
| SCHEMBL6792471 | 0.87 | PARP1 (0.57) | HPGDPARP1ROCK1 | |
| SCHEMBL6783254 | 0.86 | PARP1 (0.54) | HPGDPARP1ROCK1 | |
| SCHEMBL6786416 | 0.86 | PARP1 (0.54) | HPGDPARP1ROCK1 | |
| SCHEMBL12231987 | 0.85 | MAPK8 (0.64) | HPGDSMN1; SMN2MAPK8MAPK10MAPK14 | |
| Hydrochloric Acid SCHEMBL6786545 | 0.85 | PARP1 (0.53) | HPGDPARP1ROCK1 | |
| SCHEMBL6787452 | 0.85 | LMNA (0.57) | HPGDSMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL6787186 | 0.84 | LMNA (0.56) | HPGDSMN1; SMN2MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6677333-B1 | ANTIISCHEMIC AGENTS; BRAIN, CARDIOVASCULAR, MUSCULAR, AND GASTROINTESTINAL DISORDERS; ANALGESICS, ANTIDIABETIC AGENTS; RETROVIRUS SENSITIZERS; ALZHEIMER*S DISEASE | ONO PHARMACEUTICAL CO., LTD. (JP) | 2004-01-13 | — | — | US | claimed |
| EP-1148053-A1 | 2H-PHTHALAZIN-1-ONE DERIVATIVES AND DRUGS COMPRISING THESE DERIVATIVES AS THE ACTIVE INGREDIENT | ONO PHARMACEUTICAL CO., LTD. (JP) | 2001-10-24 | — | — | EP | claimed |