Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 11/20 | 0.38 |
| ▸ | MMP9 | P14780 | 9/20 | 0.38 |
| ▸ | MMP1 | P03956 | 3/20 | 0.38 |
| ▸ | MMP3 | P08254 | 2/20 | 0.38 |
| ▸ | MMP7 | P09237 | 1/20 | 0.38 |
| ▸ | MMP13 | P45452 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MMP8 | P22894 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6795149 | 0.82 | MMP2 (0.39) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL6784130 | 0.75 | MMP2 (0.41) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL6788993 | 0.74 | MMP2 (0.55) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL6790746 | 0.74 | MMP2 (0.42) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL6783922 | 0.74 | MMP2 (0.55) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL7456835 | 0.72 | MMP2 (0.40) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL7444559 | 0.71 | MMP2 (0.48) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL7360995 | 0.71 | NPC1 (0.53) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL7450056 | 0.71 | MMP2 (0.41) | MMP2MMP9MMP1MMP3MMP7 | |
| SCHEMBL6789040 | 0.71 | GAA (0.42) | MMP2MMP9MMP1MMP3MMP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | claimed |
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |