SCHEMBL6789417

SCHEMBL6789417

O=C(Nc1ccc(S(=O)(=O)CC(COc2ccccc2)C(=O)NO)cc1)c1ccc(Cl)cc1

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ENPP1 P22413 3/20 0.51
ENPP3 O14638 2/20 0.51
MEN1 O00255 6/20 0.48
KMT2A Q03164 6/20 0.48
PRMT1 Q99873 3/20 0.48
MMP2 P08253 3/20 0.46
MMP3 P08254 2/20 0.46
MMP13 P45452 2/20 0.46
BCL2L1 Q07817 1/20 0.46
MCL1 Q07820 1/20 0.46
HPGD P15428 1/20 0.46
MMP9 P14780 2/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
TP53 P04637 1/20 0.45
MMP1 P03956 1/20 0.45
MMP8 P22894 1/20 0.45
ENPP2 Q13822 2/20 0.44
P2RY2 P41231 1/20 0.44
GPR17 Q13304 1/20 0.44
MAPT P10636 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6790296 0.91 ENPP1 (0.54) ENPP1ENPP3MEN1KMT2APRMT1
SCHEMBL6787274 0.89 MEN1 (0.45) MEN1KMT2APRMT1MMP2MMP3
SCHEMBL6783348 0.87 BCL2L1 (0.49) MMP2MMP3MMP13BCL2L1MCL1
SCHEMBL6784814 0.83 PRMT1 (0.52) MEN1KMT2APRMT1MMP2MMP3
SCHEMBL6789365 0.82 KMT2A (0.48) ENPP1ENPP3MEN1KMT2APRMT1
SCHEMBL6789427 0.81 ENPP1 (0.48) ENPP1ENPP3MEN1KMT2APRMT1
SCHEMBL6783079 0.80 MMP2 (0.58) MEN1KMT2AMMP2MMP3MMP13
SCHEMBL6789927 0.80 MEN1 (0.43) MEN1KMT2ASMN1; SMN2TP53P2RY2
SCHEMBL6789958 0.79 MMP2 (0.48) MEN1KMT2AMMP2MMP3MMP13
SCHEMBL6788890 0.76 BCL2L1 (0.49) MMP2MMP3MMP13BCL2L1MCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1200398-A1 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2002-05-02 EP claimed
WO-2001005756-A1 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN SPA (IT) 2001-01-25 WO claimed
US-6765003-B1 ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, PHARMACIA ITALIA, SPA (IT) 2004-07-20 US disclosed
EP-1200398-A1 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS Pharmacia Italia S.p.A. (IT) 2002-05-02 EP disclosed
WO-2001005756-A1 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN SPA (IT) 2001-01-25 WO disclosed