Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 5/20 | 0.48 |
| ▸ | ENPP2 | Q13822 | 3/20 | 0.48 |
| ▸ | GPR17 | Q13304 | 3/20 | 0.46 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.46 |
| ▸ | ENPP3 | O14638 | 4/20 | 0.45 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 2/20 | 0.43 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.43 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790296 | 0.90 | ENPP1 (0.54) | ENPP1ENPP2GPR17P2RY2ENPP3 | |
| SCHEMBL7450556 | 0.89 | MEN1 (0.44) | GPR17P2RY2MEN1KMT2AMAPT | |
| SCHEMBL6790714 | 0.86 | ADAMTS4 (0.47) | MMP2MMP9MMP3MMP13HSD17B10 | |
| SCHEMBL6784814 | 0.82 | PRMT1 (0.52) | MEN1KMT2ASMN1; SMN2MMP2MMP9 | |
| SCHEMBL6789417 | 0.81 | ENPP1 (0.51) | ENPP1ENPP2GPR17P2RY2ENPP3 | |
| SCHEMBL6789927 | 0.80 | MEN1 (0.43) | GPR17P2RY2MEN1KMT2AMAPT | |
| SCHEMBL6783079 | 0.79 | MMP2 (0.58) | MEN1KMT2AMAPTSMN1; SMN2GAA | |
| SCHEMBL6789958 | 0.78 | MMP2 (0.48) | MEN1KMT2AMAPTMMP2MMP9 | |
| SCHEMBL6787286 | 0.75 | KMT2A (0.53) | MEN1KMT2AMAPTSMN1; SMN2GAA | |
| SCHEMBL7447715 | 0.75 | KMT2A (0.53) | MEN1KMT2AMAPTSMN1; SMN2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | claimed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | claimed |
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | disclosed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | disclosed |