Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.69 |
| ▸ | GLS | O94925 | 1/20 | 0.47 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | HTR7 | P34969 | 1/20 | 0.46 |
| ▸ | HRH1 | P35367 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7407102 | 0.90 | ACHE (0.78) | ACHEGLSHTR1AHTR7HRH1 | |
| SCHEMBL16015939 | 0.85 | ACHE (0.56) | ACHEGLSHTR1AHTR7HRH1 | |
| Methyl Alcohol SCHEMBL28751304 | 0.85 | ACHE (0.77) | ACHEGLSCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL4245809 | 0.85 | ACHE (0.71) | ACHEGLSHTR1AHTR7HRH1 | |
| SCHEMBL5109433 | 0.83 | CYP1A2 (0.51) | ACHEGLSCYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6950324 | 0.82 | ACHE (1.00) | ACHE | |
| SCHEMBL4632588 | 0.82 | ACHE (0.68) | ACHEGLSHTR1AHTR7HRH1 | |
| Hydrochloric Acid SCHEMBL11718055 | 0.81 | ACHE (0.66) | ACHEGLSHTR1AHTR7HRH1 | |
| SCHEMBL27682918 | 0.78 | ACHE (0.76) | ACHE | |
| SCHEMBL7451684 | 0.78 | ACHE (0.62) | ACHEGLSHTR1AHTR7HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1545508-B | 1,2,4-trioxolane antimalarials | MEDICINES MALARIA VENTURE MMV | 2012-06-06 | — | — | CN | disclosed |
| US-6825230-B2 | PEROXY COMPOUNDS SUCH AS ADAMANTANE-2-SPIRO-3'-8'-((1'S)-10'-CAMPHORSULFONYL)-1',2',4'-TRIOXA-8' -AZASPIRO(4.5) DECANE, USED FOR PROPHYLAXIS OF MALARIA OR SCHISTOSOMIASIS INFECTIONS | MEDICINES FOR MALARIA VENTURE MMV (CH) | 2004-11-30 | — | — | US | disclosed |
| CN-1545508-A | 1,2,4-trioxolane antimalarials | ű��ҩ�﹫˾ | 2004-11-10 | — | — | CN | disclosed |
| EP-1414813-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | Medicines for Malaria Venture (CH) | 2004-05-06 | — | — | EP | disclosed |
| US-20040039008-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | MEDICINES FOR MALARIA VENTURES MMV (CH) | 2004-02-26 | — | — | US | disclosed |
| WO-2003000676-A1 | 1,2,4-TRIOXOLANE ANTIMALARIALS | MEDICINES FOR MALARIA VENTURE (CH) | 2003-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040039008-A1 | Spiro and dispiro 1,2,4-trioxolane antimalarials | DHODH, THPO, SQLE | ACHE 2333/4885GLS 2647/4885HTR1A 1292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.