Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 6/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6299855 | 0.85 | ALDH1A1 (0.45) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL6791413 | 0.77 | HTT (0.51) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL14387569 | 0.77 | ALDH1A1 (0.41) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL3582642 | 0.75 | ALDH1A1 (0.49) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL23932999 | 0.75 | SMN1; SMN2 (0.39) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL30776685 | 0.75 | SMN1; SMN2 (0.39) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL6796985 | 0.74 | TTR (0.47) | ALDH1A1MEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4883148 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL13931955 | 0.74 | ALDH1A1 (0.47) | ALDH1A1MAPK1MEN1KMT2AMAPT | |
| SCHEMBL2258930 | 0.73 | VCAM1 (0.58) | ALDH1A1MAPK1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6784184-B2 | FOR THERAPY OF RAS- ONCOGENE-DEPENDENT TUMORS, SUCH AS CANCERS OF PANCREAS, COLON, BLADDER, AND THYROID; USEFUL FOR CONTROLLING METASTASIS, SUPPRESSING ANGIOGENESIS, INDUCING APOPTOSIS, AND RAS-ASSOCIATED PROLIFERATIVE DISEASES | WYETH HOLDINGS CORPORATION | 2004-08-31 | — | — | US | disclosed |
| US-6605628-B1 | Treatment of ras oncogene-dependent tumors; controlling metastasis, suppressing angiogenesis, inducing apoptosis | WYETH HOLDINGS CORPORATION | 2003-08-12 | — | — | US | disclosed |