Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 6/20 | 0.43 |
| ▸ | MMP9 | P14780 | 6/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | MMP3 | P08254 | 5/20 | 0.43 |
| ▸ | MMP1 | P03956 | 3/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7454617 | 1.00 | ALDH1A1 (0.46) | ALDH1A1MMP2MMP9MMP8NPC1 | |
| SCHEMBL6784793 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MMP2MMP9MMP8NPC1 | |
| SCHEMBL7448510 | 0.88 | ALDH1A1 (0.46) | ALDH1A1MMP2MMP9MMP8NPC1 | |
| SCHEMBL6789601 | 0.85 | MMP2 (0.41) | ALDH1A1MMP2MMP9MMP8NPC1 | |
| SCHEMBL6784051 | 0.85 | MMP2 (0.52) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL6790233 | 0.80 | MMP2 (0.45) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL6788702 | 0.77 | MMP2 (0.45) | MMP2MMP9MMP8MMP3MMP1 | |
| SCHEMBL6787862 | 0.77 | ALDH1A1 (0.46) | ALDH1A1MMP2MMP9RAB9AMMP3 | |
| SCHEMBL7365162 | 0.76 | MMP2 (0.51) | ALDH1A1MMP2MMP9MMP8NPC1 | |
| SCHEMBL6783348 | 0.76 | BCL2L1 (0.49) | MMP2MMP9MMP8MMP3MMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1200398-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | Pharmacia Italia S.p.A. (IT) | 2002-05-02 | — | — | EP | claimed |
| WO-2001005756-A1 | 3-ARYLSULFONYL-2-(SUBSTITUTED METHYL)PROPANOIC ACID DERIVATES AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN SPA (IT) | 2001-01-25 | — | — | WO | claimed |
| US-6765003-B1 | ANTICARCINOGENIC, ANTITUMOR, AND ANTIMETASTASIS AGENTS; RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, OSTEOPOROSIS, MULTIPLE SCLEROSIS, STROKE, ARTERIOSCLEROSIS, | PHARMACIA ITALIA, SPA (IT) | 2004-07-20 | — | — | US | disclosed |