Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | NCF1 | P14598 | 6/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.42 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | GPR3 | P46089 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6790532 | 0.85 | CYP1A2 (0.60) | CYP1A2NCF1KDM4EUSP2ALDH1A1 | |
| SCHEMBL30367038 | 0.77 | CYP1A2 (0.50) | CYP1A2NCF1KDM4EALDH1A1MAPT | |
| SCHEMBL30367104 | 0.77 | CYP1A2 (0.50) | CYP1A2NCF1 | |
| SCHEMBL30367213 | 0.76 | CYP1A2 (0.49) | CYP1A2NCF1KDM4EALDH1A1MAPT | |
| SCHEMBL4863068 | 0.76 | NCF1 (0.50) | CYP1A2NCF1KDM4EALDH1A1MAPT | |
| SCHEMBL6185025 | 0.73 | NCF1 (0.51) | CYP1A2NCF1KDM4EMAPTL3MBTL1 | |
| SCHEMBL8894367 | 0.73 | CYP1A2 (0.50) | CYP1A2NCF1MAPTL3MBTL1CYP2C19 | |
| SCHEMBL898963 | 0.73 | NCF1 (0.53) | CYP1A2NCF1KDM4EMEN1HTT | |
| SCHEMBL2641557 | 0.73 | CYP1A2 (0.64) | CYP1A2NCF1KDM4EUSP2ALDH1A1 | |
| SCHEMBL29502790 | 0.72 | CYP1A2 (1.00) | CYP1A2NCF1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6825215-B2 | N-HYDROXY-2-(2-(((4-((2-METHYL-4-QUINOLINYL)METHOXY)PHENYL) -SULFONYL)METHYL)-2-PYRROLIDINYL)ACETAMIDE, FOR EXAMPLE AND OTHER QUINOLINE CONTAINING N-HYDROXYACETAMIDE DERIVATIVES | BRISTOL-MYERS SQUIBB PHARMA COMPANY | 2004-11-30 | — | — | US | disclosed |