Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | IDO2 | Q6ZQW0 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680906 | 0.85 | ALDH1A1 (0.46) | NPC1RAB9AKDM4ELMNASMN1; SMN2 | |
| SCHEMBL21185651 | 0.81 | KDM4E (0.44) | KDM4ELMNAGAAKMT2AALDH1A1 | |
| SCHEMBL9055106 | 0.77 | MAPK8 (0.49) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL17478630 | 0.74 | NPC1 (0.55) | NPC1RAB9AHTTDHODHTP53 | |
| SCHEMBL28247345 | 0.72 | HTT (0.55) | NPC1RAB9AHTTDHODHTP53 | |
| SCHEMBL17883584 | 0.72 | GRM2 (0.72) | NPC1RAB9AKDM4ELMNAKMT2A | |
| SCHEMBL9056238 | 0.71 | ALDH1A1 (0.50) | NPC1RAB9AKDM4ELMNAHTT | |
| SCHEMBL4070919 | 0.71 | KDM4E (0.57) | KDM4ELMNAKMT2AALDH1A1HSD17B10 | |
| SCHEMBL21383288 | 0.71 | MAPK1 (0.58) | KDM4ELMNAHTTKMT2AALDH1A1 | |
| SCHEMBL679241 | 0.71 | LMNA (0.57) | KDM4ELMNAKMT2AALDH1A1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2310382-B1 | AMIDOPHENOXYINDAZOLES USEFUL AS INHIBITORS OF C-MET | LILLY CO ELI (US) | 2012-02-22 | — | — | EP | disclosed |