Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.34 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 3/20 | 0.33 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 3/20 | 0.32 |
| ▸ | MAOB | P27338 | 3/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6791576 | 0.79 | KDM4E (0.37) | KDM4EALDH1A1HPGDADRB2ADRB1 | |
| SCHEMBL30558421 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL3994779 | 0.77 | KDM4E (0.54) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL21715395 | 0.74 | ALDH1A1 (0.54) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL8125887 | 0.72 | MAOB (0.55) | MAOAMAOB | |
| SCHEMBL29660410 | 0.68 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL3987174 | 0.68 | KDM4E (0.67) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL4119937 | 0.67 | ALDH1A1 (0.60) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL611321 | 0.67 | ALDH1A1 (0.81) | KDM4EALDH1A1HPGDHSD17B1 | |
| SCHEMBL8615195 | 0.66 | MAOA (0.39) | KDM4EALDH1A1HPGDHSD17B1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
| EP-0764159-B1 | C -4 AMIDE SUBSTITUTED COMPOUNDS AND THEIR USE AS THERAPEUTIC AGENTS | SMITHKLINE BEECHAM PLC (GB) | 2000-08-09 | — | — | EP | disclosed |
| US-5843989-A | C4 -amide substituted compounds and their use as therapeutic agents | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-12-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | KDM4E 2167/4885ALDH1A1 4449/4885HPGD 814/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.