Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 17/20 | 0.40 |
| ▸ | ADRA1D | P25100 | 15/20 | 0.40 |
| ▸ | ADRA1B | P35368 | 13/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.38 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.38 |
| ▸ | ADRA2C | P18825 | 4/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7975022 | 0.92 | ADRA1A (0.46) | ADRA1AADRA1DADRA1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL6406286 | 0.83 | ADRA1A (0.47) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6786204 | 0.80 | ADRA1A (0.50) | ADRA1AADRA1DADRA1BSMN1; SMN2MAPT | |
| SCHEMBL8659585 | 0.76 | ADRA1A (0.48) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6782745 | 0.75 | ADRA1A (0.52) | ADRA1AADRA1DADRA1BADRA2AADRA2B | |
| SCHEMBL6793160 | 0.74 | ADRA1A (0.52) | ADRA1AADRA1DADRA1BSMN1; SMN2MAPT | |
| SCHEMBL6785064 | 0.70 | ADRA1A (0.54) | ADRA1AADRA1DADRA1BSMN1; SMN2MAPT | |
| SCHEMBL6786820 | 0.69 | ADRA1D (0.46) | ADRA1AADRA1DADRA1BSMN1; SMN2ALDH1A1 | |
| SCHEMBL7975023 | 0.69 | ADRA1A (0.42) | ADRA1AADRA1DADRA1BSMN1; SMN2MAPT | |
| SCHEMBL6785748 | 0.68 | ADRA1A (0.44) | ADRA1AADRA1DADRA1BADRA2AADRA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6727257-B1 | HYPOTENSIVE AGENTS FOR INTRAOCULAR PRESSURE; ANTICHOLESTEROL AGENTS; RELAXING URINARY TRACT TISSUE; BENIGN PROSTATIC HYPERPLASIA, IMPOTENCY, AND CARDIOVASCULAR DISORDERS; ANTIARRHYTHMIA AGENTS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2004-04-27 | — | — | US | disclosed |
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |
| US-6248747-B1 | TREATMENT OF BENIGN PROSTATIC HYPERPLASIA WITH ANTAGONISTS SELECTIVE FOR CLONED HUMAN ALPHA-1C RECEPTORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-06-19 | — | — | US | disclosed |
| US-5942517-A | ANTAGONIST OF ALPHA(1C) RECEPTORS; TREATMENT OF BENIGN PROSTATIC HYPERPLASIA | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1999-08-24 | — | — | US | disclosed |
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |
| WO-1996014846-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-05-23 | — | — | WO | disclosed |