Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 7/20 | 0.50 |
| ▸ | RAB9A | P51151 | 6/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 1/20 | 0.50 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.50 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.50 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964249 | 0.76 | TSHR (0.50) | KDM4EALDH1A1TDP1NPC1RAB9A | |
| SCHEMBL31247689 | 0.71 | KDM4E (0.50) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL1781579 | 0.70 | KDM4E (0.56) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL498897 | 0.69 | KDM4E (1.00) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL1743331 | 0.68 | KDM4E (0.61) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL3610416 | 0.68 | HDAC8 (0.39) | KDM4EALDH1A1MAPTTDP1NPC1 | |
| SCHEMBL36011 | 0.68 | KDM4E (0.61) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL30596386 | 0.68 | KDM4E (0.61) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL17049366 | 0.68 | KDM4E (0.51) | KDM4EALDH1A1MAPTHPGDMEN1 | |
| SCHEMBL9967122 | 0.68 | KDM4E (0.49) | KDM4EALDH1A1MAPTHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 524 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5142545-A | LASER DYE | LAMBDA PHYSIK GESELLSCHAFT ZUR HERSTELLUNG VON LASERN MBH (DE) | 1992-08-25 | — | — | US | claimed |
| US-4891305-A | LASERS | RICOH CO., LTD. (JP) | 1990-01-02 | — | — | US | claimed |
| US-3970461-A | Fogged, direct-positive silver halide emulsion containing carbocyanine dye having indolenine nucleus | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | claimed |
| US-12544362-B2 | Methods of treating acute respiratory distress syndrome with activators of Tie-2 | EyePoint Pharmaceuticals, Inc. (US) | 2026-02-10 | — | — | US | disclosed |
| US-12152023-B2 | Compositions, formulations and methods for treating ocular diseases | EyePoint Pharmaceuticals, Inc. (US) | 2024-11-26 | — | — | US | disclosed |
| US-20240299367-A1 | METHODS OF TREATING ACUTE RESPIRATORY DISTRESS SYNDROME WITH ACTIVATORS OF TIE-2 | EyePoint, Inc. | 2024-09-12 | — | — | US | disclosed |
| US-20230139250-A1 | FORMULATIONS OF TIE-2 ACTIVATORS AND METHODS OF USE THEREOF | EYEPOINT PHARMACEUTICALS INC (US) | 2023-05-04 | — | — | US | disclosed |
| EP-4101297-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | Aerpio Pharmaceuticals, Inc. (US) | 2022-12-14 | — | — | EP | disclosed |
| US-20220274976-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | EyePoint, Inc. | 2022-09-01 | — | — | US | disclosed |
| US-11413242-B2 | Formulations of Tie-2 activators and methods of use thereof | EyePoint Pharmaceuticals, Inc. (US) | 2022-08-16 | — | — | US | disclosed |
| US-20220016086-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES | EyePoint Pharmaceuticals, Inc. | 2022-01-20 | — | — | US | disclosed |
| US-3994733-A | CYANINE DYES, A BENZOTHIAZOLE, OR BENZOTHIAZOLONE, OR NAPHTHOTHIAZOLE, OR NAPHTHOTHIAZOLONE, OR A QUINOLONE | FUJI PHOTO FILM CO., LTD. (JA) | 1976-11-30 | — | — | US | disclosed |
| US-3988154-A | Photographic supports and elements utilizing photobleachable omicron-nitroarylidene dyes | EASTMAN KODAK COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
| US-3988156-A | Photographic supports and elements utilizing photobleachable o-nitroarylidene dyes | EASTMAN KODAK COMPANY (US) | 1976-10-26 | — | — | US | disclosed |
| US-3984248-A | Photographic polymeric film supports containing photobleachable o-nitroarylidene dyes | EASTMAN KODAK COMPANY (US) | 1976-10-05 | — | — | US | disclosed |
| US-3976493-A | CYANINE DYES | POLAROID CORPORATION (US) | 1976-08-24 | — | — | US | disclosed |
| US-3970461-A | Fogged, direct-positive silver halide emulsion containing carbocyanine dye having indolenine nucleus | FUJI PHOTO FILM CO., LTD. (JA) | 1976-07-20 | — | — | US | disclosed |
| US-3943142-A | Dye intermediates and their preparation and use in the synthesis of methine dyes | EASTMAN KODAK COMPANY (US) | 1976-03-09 | — | — | US | disclosed |
| US-3936308-A | Photographic emulsions containing methine dyes having a 1H-imidazo[4,5-b]pyrazine nucleus | EASTMAN KODAK COMPANY (US) | 1976-02-03 | — | — | US | disclosed |
| US-3935010-A | IMIDAZOQUINOXALINE DESENSITIZER | EASTMAN KODAK COMPANY (US) | 1976-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240299367-A1 | METHODS OF TREATING ACUTE RESPIRATORY DISTRESS SYNDROME WITH ACTIVATORS OF TIE-2 | TIE1, TEK, VASP | KDM4E 2911/4885ALDH1A1 3868/4885MAPT 4246/4885 |
| US-11413242-B2 | Formulations of Tie-2 activators and methods of use thereof | TIE1, TEK, KDR | KDM4E 1190/4885ALDH1A1 3387/4885MAPT 3618/4885 |
| US-20220016086-A1 | COMPOSITIONS AND METHODS FOR TREATING OCULAR EDEMA, NEOVASCULARIZATION AND RELATED DISEASES | FLT4, VEGFA, AQP3 | KDM4E 4502/4885ALDH1A1 3159/4885MAPT 1793/4885 |
| US-12544362-B2 | Methods of treating acute respiratory distress syndrome with activators of Tie-2 | TIE1, ACE2, TEK | KDM4E 1524/4885ALDH1A1 4498/4885MAPT 582/4885 |
| US-20220274976-A1 | COMPOSITIONS, FORMULATIONS AND METHODS FOR TREATING OCULAR DISEASES | TIE1, TEK, KDR | KDM4E 1897/4885ALDH1A1 3657/4885MAPT 650/4885 |
| US-12152023-B2 | Compositions, formulations and methods for treating ocular diseases | TIE1, TEK, KDR | KDM4E 1897/4885ALDH1A1 3657/4885MAPT 650/4885 |
| US-20230139250-A1 | FORMULATIONS OF TIE-2 ACTIVATORS AND METHODS OF USE THEREOF | TIE1, TEK, KDR | KDM4E 1190/4885ALDH1A1 3387/4885MAPT 3618/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.