Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | CCND3 | P30281 | 1/20 | 0.30 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.30 |
| ▸ | KDM1A | O60341 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6794419 | 0.80 | HRH4 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL4267636 | 0.79 | AR (0.32) | — | |
| Trifluoroacetic Acid SCHEMBL6794506 | 0.79 | HRH4 (0.36) | CDK4CCNA2CDK2CCND3CDK6 | |
| Trifluoroacetic Acid SCHEMBL4270922 | 0.79 | MAPKAPK2 (0.36) | KDM1A | |
| Trifluoroacetic Acid SCHEMBL4262642 | 0.79 | MAPKAPK2 (0.33) | CCNA2CDK2 | |
| Trifluoroacetic Acid SCHEMBL6794975 | 0.78 | PIM1 (0.36) | CDK4CCNA2CDK2CCND3CDK6 | |
| Trifluoroacetic Acid SCHEMBL6791878 | 0.78 | — | — | |
| Trifluoroacetic Acid SCHEMBL6792038 | 0.78 | IKBKB (0.35) | CDK4CCNA2CDK2CCND3CDK6 | |
| Trifluoroacetic Acid SCHEMBL6787950 | 0.77 | PARP1 (0.35) | CCNA2CDK2KDM1A | |
| Trifluoroacetic Acid SCHEMBL4267055 | 0.77 | IKBKB (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | GRM5 1026/4885PDGFRB 1409/4885KDR 1991/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.