Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 7/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 5/20 | 0.34 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.34 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.34 |
| ▸ | PLK1 | P53350 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6792620 | 0.93 | ALDH1A1 (0.37) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL4270462 | 0.91 | CDK2 (0.41) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6793603 | 0.89 | CDK2 (0.33) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6791165 | 0.87 | PLK1 (0.36) | CDK2PDPK1PLK1 | |
| SCHEMBL6793555 | 0.86 | CDK2 (0.33) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6793561 | 0.85 | CDK2 (0.32) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6787093 | 0.85 | MCHR2 (0.34) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6789104 | 0.85 | AURKA (0.31) | CDK2AURKACCNA2CCNA1PLK1 | |
| Trifluoroacetic Acid SCHEMBL6791881 | 0.85 | CHRM2 (0.35) | CDK2PDPK1AURKACCNA2CCNA1 | |
| Trifluoroacetic Acid SCHEMBL1656626 | 0.85 | CDK2 (0.34) | CDK2PDPK1AURKACCNA2CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CDK2 29/4885PDPK1 87/4885AURKA 341/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.