Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK1 | P53350 | 3/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | NAMPT | P43490 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3R2 | O00459 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | PIK3R5 | Q8WYR1 | 1/20 | 0.33 |
| ▸ | PIK3R3 | Q92569 | 1/20 | 0.33 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | PRKCG | P05129 | 1/20 | 0.32 |
| ▸ | PRKCB | P05771 | 1/20 | 0.32 |
| ▸ | PRKCA | P17252 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.32 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794733 | 0.89 | BRAF (0.34) | PLK1KDM4CBRAFMAPK3MAPK1 | |
| Trifluoroacetic Acid SCHEMBL4270462 | 0.88 | CDK2 (0.41) | PLK1KDM4CBRAFMAPK3MAPK1 | |
| Trifluoroacetic Acid SCHEMBL6792620 | 0.88 | ALDH1A1 (0.37) | PLK1PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6793603 | 0.88 | CDK2 (0.33) | PLK1PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6793544 | 0.87 | CDK2 (0.35) | PLK1PDPK1CDK2 | |
| SCHEMBL6791171 | 0.86 | PLK1 (0.37) | PLK1KDM4CBRAFMAPK3MAPK1 | |
| Trifluoroacetic Acid SCHEMBL6791540 | 0.84 | CYP1A2 (0.34) | MAPK1NAMPTKCNH2PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL1655186 | 0.84 | KDM4C (0.34) | KDM4CNAMPTPDPK1CDK2APAF1 | |
| Trifluoroacetic Acid SCHEMBL6792435 | 0.84 | PTGES (0.35) | PLK1PDPK1CDK2 | |
| Trifluoroacetic Acid SCHEMBL6793561 | 0.84 | CDK2 (0.32) | PLK1PDPK1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | PLK1 101/4885KDM4C 3390/4885BRAF 316/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.