Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KLK7 | P49862 | 2/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCND3 | P30281 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.35 |
| ▸ | CTSS | P25774 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792409 | 0.72 | TEAD2 (0.38) | CDK4CCNA2CDK2CCND3CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6792793 | 0.72 | CDK2 (0.37) | ROCK2CDK4CCNA2CDK2CCND3 | |
| SCHEMBL6791186 | 0.70 | BRAF (0.36) | ROCK2CDK4CCNA2CDK2CCND3 | |
| SCHEMBL6792783 | 0.69 | CDK4 (0.35) | ROCK2CDK4CCNA2CDK2CCND3 | |
| SCHEMBL6786987 | 0.69 | ELANE (0.36) | CDK4CCNA2CDK2CCND3CCNA1 | |
| SCHEMBL6791848 | 0.69 | BRAF (0.37) | ROCK2CDK4CCNA2CDK2CCND3 | |
| SCHEMBL12873003 | 0.68 | PPARA (0.57) | SYKPPARACTSSCTSK | |
| SCHEMBL3881683 | 0.68 | CTSS (0.65) | KLK7SYKPPARAKLK5CTSS | |
| SCHEMBL12203688 | 0.68 | PPARA (0.57) | SYKPPARACTSSCTSK | |
| SCHEMBL8696309 | 0.68 | CTSS (0.65) | KLK7SYKPPARAKLK5CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ROCK2 317/4885ADORA1 3050/4885KLK7 948/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.