Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 2/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
| ▸ | CCND3 | P30281 | 1/20 | 0.37 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | EIF2AK3 | Q9NZJ5 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CDC7 | O00311 | 1/20 | 0.33 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.33 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6792783 | 0.89 | CDK4 (0.35) | CDK2CDK4CCNA2CCND3CCNA1 | |
| Trifluoroacetic Acid SCHEMBL1655691 | 0.84 | CDK2 (0.32) | CDK2CCNA2CCNA1ROCK2TSHR | |
| SCHEMBL6794857 | 0.83 | CYP11B1 (0.38) | CDK2CDK4CCNA2CCND3CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6788639 | 0.83 | ALDH1A1 (0.39) | CDK2CDK4CCNA2CCND3CCNA1 | |
| Hydrochloric Acid SCHEMBL6787345 | 0.83 | ROCK2 (0.32) | CDK2ROCK2NAMPTAURKA | |
| SCHEMBL1655698 | 0.82 | CYP1A2 (0.30) | HPGD | |
| Trifluoroacetic Acid SCHEMBL6791540 | 0.80 | CYP1A2 (0.34) | CDK2KDM4EHPGDNAMPTMAPK1 | |
| SCHEMBL6792630 | 0.80 | KDM4E (0.38) | CDK2CDK4CCNA2CCND3CCNA1 | |
| Trifluoroacetic Acid SCHEMBL6793066 | 0.79 | ROCK2 (0.38) | CDK2CDK4CCNA2CCND3CCNA1 | |
| Hydrochloric Acid SCHEMBL6793245 | 0.79 | CCNA2 (0.37) | CDK2CDK4CCNA2CCND3CCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | CDK2 29/4885CDK4 154/4885CCNA2 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.