Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.50 |
| ▸ | EBP | Q15125 | 2/20 | 0.50 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.50 |
| ▸ | EBPL | Q9BY08 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.47 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.47 |
| ▸ | DHCR7 | Q9UBM7 | 1/20 | 0.46 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2952076 | 0.82 | ADRB1 (0.48) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL2949961 | 0.81 | CHKA (0.56) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL2948029 | 0.76 | EBP (0.51) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL2950817 | 0.75 | CHKA (0.54) | SIGMAR1EBPTMEM97EBPLABCB1 | |
| SCHEMBL7663433 | 0.74 | CHEK1 (0.48) | — | |
| SCHEMBL310628 | 0.72 | SIGMAR1 (0.54) | SIGMAR1EBPTMEM97EBPLADRA1D | |
| SCHEMBL1299348 | 0.71 | SIGMAR1 (0.79) | SIGMAR1EBPTMEM97EBPL | |
| SCHEMBL2948792 | 0.71 | ABCB1 (0.53) | ABCB1ABCC1 | |
| SCHEMBL8075010 | 0.71 | SIGMAR1 (0.89) | SIGMAR1EBPTMEM97EBPL | |
| Hydrochloric Acid SCHEMBL1298925 | 0.71 | SIGMAR1 (0.77) | SIGMAR1EBPTMEM97EBPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6720338-B2 | BCL-X1 INHIBITING COMPOSITIONS AND METHODS OF PROMOTING APOPTOSIS IN A MAMMAL | ABBOTT LABORATORIES | 2004-04-13 | — | — | US | disclosed |