Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 17/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 14/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 14/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.32 |
| ▸ | GRK2 | P25098 | 1/20 | 0.32 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.31 |
| ▸ | CIT | O14578 | 2/20 | 0.31 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.31 |
| ▸ | STK10 | O94804 | 2/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.31 |
| ▸ | ABL1 | P00519 | 2/20 | 0.31 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
| ▸ | ERBB3 | P21860 | 2/20 | 0.31 |
| ▸ | JAK1 | P23458 | 2/20 | 0.31 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.31 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.31 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6794720 | 1.00 | BRAF (0.34) | BRAFMAPK3MAPK1SIGMAR1ROCK2 | |
| SCHEMBL6793213 | 0.81 | SIGMAR1 (0.35) | SIGMAR1TGFBR1MAPK10 | |
| SCHEMBL4260846 | 0.76 | SIGMAR1 (0.36) | SIGMAR1 | |
| SCHEMBL6794985 | 0.75 | SIGMAR1 (0.32) | SIGMAR1 | |
| SCHEMBL460089 | 0.73 | CDC7 (0.39) | SIGMAR1 | |
| SCHEMBL6798659 | 0.72 | SIGMAR1 (0.36) | SIGMAR1 | |
| SCHEMBL6795084 | 0.71 | GPR119 (0.35) | — | |
| SCHEMBL2687562 | 0.70 | HPGD (0.53) | BRAFMAPK3MAPK1SIGMAR1ROCK2 | |
| SCHEMBL2885100 | 0.70 | HPGD (0.53) | BRAFMAPK3MAPK1SIGMAR1ROCK2 | |
| SCHEMBL2687559 | 0.70 | HPGD (0.53) | BRAFMAPK3MAPK1SIGMAR1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | BRAF 316/4885MAPK3 46/4885MAPK1 54/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.