Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM7 | Q14831 | 3/20 | 0.51 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6644702 | 0.87 | GRM7 (0.54) | GRM7CA1CA2HRH3MTNR1A | |
| SCHEMBL5097175 | 0.85 | OPRM1 (0.48) | OPRM1ROCK2MAPTMEN1KMT2A | |
| SCHEMBL6639610 | 0.81 | GRM7 (0.52) | GRM7HRH3MTNR1AMTNR1BROCK2 | |
| SCHEMBL3315249 | 0.81 | MEN1 (0.41) | OPRM1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL9282167 | 0.81 | GAA (0.51) | OPRM1MAPTMEN1KMT2ACYP3A4 | |
| SCHEMBL3313904 | 0.79 | OPRM1 (0.42) | OPRM1MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL7139021 | 0.77 | KDM1A (0.53) | GRM7CA1CA2HRH3MTNR1A | |
| Hydrochloric Acid SCHEMBL6052700 | 0.75 | KDM1A (0.51) | GRM7CA1CA2HRH3MTNR1A | |
| SCHEMBL10447052 | 0.73 | GRM7 (0.53) | GRM7CA1CA2HRH3MTNR1A | |
| Hydrochloric Acid SCHEMBL7144136 | 0.73 | MAPT (0.44) | GRM7CA1CA2HRH3MTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6743794-B2 | MULTIDRUG RESISTANCE PROTEIN; CANCER; 3-(9-CHLORO-3-METHYL-4-OXO-5H-ISOXAZOLO(4,3-C)QUINOLIN-5-YL)) CYCLOHEXYL)-2-PIPERIDYLACETAMIDE | ELI LILLY AND COMPANY | 2004-06-01 | — | — | US | disclosed |