Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.34 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.34 |
| ▸ | PRCP | P42785 | 7/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.32 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
| ▸ | FNTA | P49354 | 1/20 | 0.32 |
| ▸ | FNTB | P49356 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 1/20 | 0.31 |
| ▸ | GUCY1A1 | Q02108 | 1/20 | 0.31 |
| ▸ | GUCY1B1 | Q02153 | 1/20 | 0.31 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6794131 | 0.94 | GRM2 (0.33) | HRH1PRCPKCNH2TMEM97SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL6787950 | 0.93 | PARP1 (0.35) | CSNK1A1CSNK1DCSNK1G2PRCPTMEM97 | |
| Trifluoroacetic Acid SCHEMBL6791463 | 0.86 | HRH4 (0.31) | — | |
| Trifluoroacetic Acid SCHEMBL6793473 | 0.85 | ALDH1A1 (0.33) | — | |
| Trifluoroacetic Acid SCHEMBL6794140 | 0.84 | PIM1 (0.35) | TMEM97SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL4270922 | 0.80 | MAPKAPK2 (0.36) | — | |
| Trifluoroacetic Acid SCHEMBL4258570 | 0.79 | CCNA2 (0.40) | CSNK1A1CSNK1DCSNK1G2 | |
| Trifluoroacetic Acid SCHEMBL6794975 | 0.79 | PIM1 (0.36) | — | |
| SCHEMBL4260268 | 0.78 | HTR2B (0.43) | TMEM97SIGMAR1 | |
| Trifluoroacetic Acid SCHEMBL6794506 | 0.78 | HRH4 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | HRH1 2236/4885CSNK1A1 157/4885CSNK1D 253/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.