Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.32 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 2/20 | 0.30 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.30 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.30 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.30 |
| ▸ | ERG | P11308 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4262524 | 0.95 | ROCK2 (0.33) | ROCK2KCNK3 | |
| SCHEMBL1655956 | 0.93 | ROCK2 (0.30) | ROCK2 | |
| SCHEMBL4257280 | 0.92 | TRPV1 (0.34) | ROCK2KCNK3HDAC1HDAC2 | |
| SCHEMBL4259042 | 0.92 | HTR5A (0.33) | ROCK2HDAC1 | |
| SCHEMBL6792403 | 0.91 | ROCK2 (0.35) | ROCK2CYP2C9 | |
| SCHEMBL4262275 | 0.90 | FLT3 (0.35) | — | |
| SCHEMBL4257197 | 0.90 | TRPV1 (0.33) | — | |
| SCHEMBL4267034 | 0.90 | ROCK2 (0.32) | ROCK2 | |
| SCHEMBL4270594 | 0.90 | AURKA (0.31) | — | |
| Trifluoroacetic Acid SCHEMBL6795493 | 0.89 | ROCK2 (0.33) | ROCK2KCNK3EP300GPBAR1HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | PHARMACIA CORPORATION | 2004-07-01 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040127492-A1 | Cyclic pyrazoles for the inhibition of mitogen activated protein kinase-activated protein kinase-2 | MKNK2, MAPKAPK2, MAP3K2 | ROCK2 317/4885KCNK3 512/4885EP300 1006/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.